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AutoInflammatory Disease Alliance Registry (AIDA)
Sponsor: University of Siena
Summary
Autoinflammatory diseases (AID) are clinical entities characterized by recurrent inflammatory attacks in absence of infection, neoplasm or deregulation of the adaptive immune system. Among them, hereditary periodic syndromes, also known as monogenic AID, represent the prototype of this disease group, caused by mutations in genes involved in the regulation of innate immunity, inflammation and cell death. Based on recent experimental acquisitions in the field of monogenic AID, several immunologic disorders have been reclassified as polygenic/multifactorial AID, sharing pathogenetic and clinical features with hereditary periodic fevers. This has paved the way to new treatment targets for patients suffering from rare diseases of unknown origin, including Behçet's disease, Still disease, Schnitzler's disease, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome, chronic recurrent multifocal osteomyelitis (CRMO), non-infectious uveitis and scleritis. Gathering information on such rare conditions is made difficult by the small number of patients, along with the difficulty of obtaining an accurate diagnosis in non-specialized clinical settings. In this context, the AIDA project promotes international collaboration among clinical centres to develop a permanent registry aimed at collecting demographic, genetic, clinical and therapeutic data of patients affected by monogenic and polygenic AID, in order to expand the current knowledge of these rare conditions.
Official title: Development of an International Multicenter Registry of Patients With Monogenic and Polygenic Autoinflammatory Diseases Aimed at Clinical and Therapeutical Data Collection and Analysis
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
3500
Start Date
2020-08-06
Completion Date
2030-08-06
Last Updated
2025-07-10
Healthy Volunteers
No
Conditions
Interventions
No intervention is foreseen by the protocol.
Patients will be observed for 10 years at least. Demographic, genetic, clinical, clinimetric, laboratory, radiologic and therapeutic data will be collected both retrospectively and prospectively during routine follow-up visits.
Locations (112)
University Algiers 1
Algiers, Algeria
Université M'Hamed Bougara de Boumerdas
Boumerdas, Algeria
Flinders University
Adelaide, Australia
University of Adelaide
Adelaide, Australia
Antwerp University Hospital
Antwerp, Belgium
Hospital das Clinicas da Faculdade de Medicina HCFMUSP
São Paulo, Brazil
Peking University People's Hospital
Beijing, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Universidad del Rosario - Escuela de Medicina Y Ciencias de La Salud
Bogotá, Colombia
Mansoura University, Faculty of Medicine
Al Mansurah, Egypt
Al-Azhar University
Cairo, Egypt
Cairo University
Cairo, Egypt
Universitätsklinikum Schleswig-Holstein
Lübeck, Germany
Evangelismos General Hospital
Athens, Greece
National and Kapodistrian University of Athens
Athens, Greece
National and Kapodistrian University of Athens
Athens, Greece
Prabha Eye Clinic & Research Centre
Bangalore, India
Postgraduate Institute of Medical Education and Research
Chandigarh, India
Shariati Hospital - Tehran University of Medical Sciences
Tehran, Iran
Azienda Ospedaliero-Universitaria Senese
Siena, Tuscany, Italy
AOUC Policlinico di Bari
Bari, Italy
University of Bari Medical School
Bari, Italy
University-Hospital of Bari - UOC Medicina Interna
Bari, Italy
University-Hospital of Bari - UOC Pediatria
Bari, Italy
University-Hospital of Bari - UOC Reumatologia
Bari, Italy
Central Hospital of Bolzano
Bolzano, Italy
ASST degli Spedali Civili - P.O. Ospedale dei Bambini
Brescia, Italy
ASST degli Spedali Civili
Brescia, Italy
Azienda Ospedaliera Universitaria di Cagliari
Cagliari, Italy
AOU Policlinico Vittorio Emanuele - Dip. Materno-Infantile
Catania, Italy
ARNAS Garibaldi - Catania
Catania, Italy
Azienda Ospedaliera di Catanzaro Pugliese Ciaccio
Catanzaro, Italy
Ospedale SS Annunziata
Chieti, Italy
Ospedale San Paolo
Civitavecchia, Italy
Arcispedale Sant'Anna
Ferrara, Italy
Azienda Ospedaliera Universitaria Careggi - SOD Medicina Interna Interdisciplinare
Florence, Italy
Azienda Ospedaliero-Universitaria Careggi - SOD Immunologia e Terapie Cellulari
Florence, Italy
Azienda Ospedaliero-Universitaria Meyer
Florence, Italy
Azienza Ospedaliero-Universitaria Careggi - SOD Reumatologia
Florence, Italy
Ospedale San Giovanni di Dio
Florence, Italy
Sapienza University - Polo Pontino
Latina, Italy
Ospedale Vito Fazzi
Lecce, Italy
ASL1 Avezzano, Sulmona, L'Aquila
L’Aquila, Italy
Università degli Studi di L'Aquila - UOC Medicina Interna e Nefrologia
L’Aquila, Italy
AOU Policlinico G. Martino
Messina, Italy
ASST Gaetano Pini/ CTO
Milan, Italy
Policlinico di Milano
Milan, Italy
ASST Fatebenefratelli Sacco - UO Medicina Generale
Milan, Italy
ASST Fatebenefratelli Sacco - UOC Reumatologia
Milan, Italy
ASST Gaetano Pini/CTO
Milan, Italy
IRCCS Ospedale San Raffaele
Milan, Italy
Ospedale Fatebenefratelli e Oftalmico
Milan, Italy
Ospedale Fatebenefratelli e Oftalmico
Milan, Italy
AORN Cardarelli
Naples, Italy
AOU Federico II
Naples, Italy
AOU Federico II
Naples, Italy
AOU Luigi Vanvitelli - UO Reumatologia
Naples, Italy
AOU Luigi Vanvitelli - UOC Pediatria 2
Naples, Italy
Azienda Ospedaliera Universitaria di Padova
Padova, Italy
ARNAS Civico Di Cristina Benfratelli
Palermo, Italy
ARNAS Ospedale Civico di Cristina Benfratelli
Palermo, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello
Palermo, Italy
Università degli Studi di Palermo
Palermo, Italy
Fondazione IRRCS San Matteo - SC Reumatologia
Pavia, Italy
Azienda Ospedaliera di Perugia
Perugia, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
University of Pisa
Pisa, Italy
AOU Policlinico Umberto I
Roma, Italy
Azienda Ospedaliera San Camillo Forlanini
Roma, Italy
IRCCS Fondazione PU Agostino Gemelli - UOC Medicina Interna Columbus
Roma, Italy
IRCCS Fondazione PU Agostino Gemelli - UOC Pediatria
Roma, Italy
Ospedale Pediatrico Bambino Gesù
Roma, Italy
Ospedale Universitario Campus Bio-Medico
Roma, Italy
Sapienza University - Polo Pontino
Roma, Italy
Università di Roma Tor Vergata
Roma, Italy
Azienda Ospedaliera Universitaria di Salerno
Salerno, Italy
ATS Sardegna
Tempio Pausania, Italy
AO Ordine Mauriziano
Torino, Italy
A.S.L. Vercelli - Ospedale S. Andrea
Vercelli, Italy
Azienda Ospedaliera Universitaria Integrata
Verona, Italy
Tripoli Children Hospital
Tripoli, Libya
Tripoli Children Hospital
Tripoli, Libya
University Hospital of Martinique
Fort-de-France, Martinique
Asociacion para Evitar la Ceguera en México
Mexico City, Mexico
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Mexico City, Mexico
Medical University of Lodz
Lodz, Poland
Central Clinical Hospital of the Ministry of National Defense - Military Institute of Medicine
Warsaw, Poland
Sf. Maria Hospital - University of Medicine and Pharmacy "Carol Davila"
Bucharest, Romania
Jazan University
Jizan, Saudi Arabia
King Faisal Specialist Hospital and Research Center
Riyadh, Saudi Arabia
King Saud University
Riyadh, Saudi Arabia
Hospital Universitario Cruces - Instituto de investigación sanitaria Biocruces
Barakaldo, Spain
Hospital Universitario Cruces
Barakaldo, Spain
Hospital Clinic of Barcelona
Barcelona, Spain
Hospital Fundación Jiménez Díaz
Madrid, Spain
Hospital Ramón y Cajal
Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz/Hospital Universitario Rey Juan Carlos
Madrid, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Hospital Universitari Doctor Peset
Valencia, Spain
Farhat Hached Hospital
Sousse, Tunisia
Çukurova University
Adana, Turkey (Türkiye)
Ankara Yıldırım Beyazıt University
Ankara, Turkey (Türkiye)
Gazi University
Ankara, Turkey (Türkiye)
Hacettepe University Faculty of Medicine
Ankara, Turkey (Türkiye)
Başakşehir Çam and Sakura City Hospital
Istanbul, Turkey (Türkiye)
Cerrahpasa Medical School Istanbul University
Istanbul, Turkey (Türkiye)
Marmara University, Research And Education Hospital
Istanbul, Turkey (Türkiye)
Dokuz Eylul University School of Medicine
Izmir, Turkey (Türkiye)
Manisa Celal Bayar University
Manisa, Turkey (Türkiye)
Sakarya University
Sakarya, Turkey (Türkiye)
Sivas Cumhuriyet University
Sivas, Turkey (Türkiye)
I. Horbachevsky Ternopil National Medical University - Ternopil Regional Children's Hospital
Ternopil, Ukraine