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Oral Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The purpose of this study is to evaluate whether FMT by frozen stool capsules in pediatric UC patients in remission after corticosteroid treatment, can modify their dysbiotic gut microbiota by increasing the richness of their microbiota at 6 months.
Official title: Pilot Study of a New Technique of Oral Fecal Transplantation Using Frozen Stool Capsules for the Maintenance Treatment of Pediatric Ulcerative Colitis.
Key Details
Gender
All
Age Range
8 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
26
Start Date
2025-07-01
Completion Date
2027-10-01
Last Updated
2025-04-17
Healthy Volunteers
Yes
Interventions
Fecal Microbiota Transplantation by Stool capsules
After colon cleansing using PolyEthylen glycol, the patient will have a colonoscopy under general anaesthesia. The patient will then receive orally FMT (frozen stools capsules prepared from healthy donor feces).
Fecal Microbiota Transplantation by Intra-rectal enemas
After colon cleansing using Polyethylen glycol, the patient will have a colonoscopy under general anaesthesia. The patient will then receive first FMT (frozen preparation of stools) by infusion in caecum during colonoscopy and the second and third doses by enemas.
Locations (3)
Department of gastroenterology, Armand Trousseau Hospital
Paris, France
Department of Pediatric Gastroenterology, Hepatology and Nutrition - Necker - Enfants Malades Hospital
Paris, France
Department of Pediatric Gastroenterology, Robert Debré Hospital
Paris, France