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Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
Sponsor: University of Minnesota
Summary
Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2025-04-03
Completion Date
2030-12-03
Last Updated
2026-02-23
Healthy Volunteers
No
Conditions
Interventions
depth electrodes
The study will be conducted at a single center, in TBI patients requiring neurosurgical intervention in the form of EVD placement. During neurosurgical intervention at the bedside in the Intensive Care Unit (ICU), a single depth electrode will be placed in the brain adjacent to the EVD catheter in the same burr hole. After EVD and depth electrode placement, continuous recording of ECoG activity as well as relevant physiological parameters will be performed for the duration of clinically indicated invasive neuromonitoring in accordance with the standard of care for TBI patients. A single recording station is currently available for data collection, therefore, with an anticipated average recording period of 14 days, the study will take greater than 210 days to complete for a total of 15 patients.
Locations (1)
Hennepin County Medical Center
Minneapolis, Minnesota, United States