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Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study (POEME)
Sponsor: University Hospital, Toulouse
Summary
TIPS is a standard for the treatment of portal hypertension related complications. However, it remains at risk of HE after TIPS (around 40% the first year). Dysbiosis plays a key role in pathophysiology of HE. Polydextrose (PDX) is consider as a prebiotic. Preliminary studies showed that PDX: 1. modified gut microbiota, enhancing "good bacteria" 2. improved gut permeability and immunity in 2 experimental models: infarction and colitis. The aim of this study is to assess PDX efficacy to prevent HE during the first 6 months after TIPS in cirrhotic patients.
Official title: Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2022-05-09
Completion Date
2025-06-30
Last Updated
2024-04-30
Healthy Volunteers
No
Conditions
Interventions
Polydextrose
PDX will be started 2 weeks before TIPS and taken daily for a 6 month period after TIPS.
Locations (1)
Toulouse University Hospital
Toulouse, France