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RECRUITING
NCT05206487
NA

Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study (POEME)

Sponsor: University Hospital, Toulouse

View on ClinicalTrials.gov

Summary

TIPS is a standard for the treatment of portal hypertension related complications. However, it remains at risk of HE after TIPS (around 40% the first year). Dysbiosis plays a key role in pathophysiology of HE. Polydextrose (PDX) is consider as a prebiotic. Preliminary studies showed that PDX: 1. modified gut microbiota, enhancing "good bacteria" 2. improved gut permeability and immunity in 2 experimental models: infarction and colitis. The aim of this study is to assess PDX efficacy to prevent HE during the first 6 months after TIPS in cirrhotic patients.

Official title: Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2022-05-09

Completion Date

2025-06-30

Last Updated

2024-04-30

Healthy Volunteers

No

Interventions

DIETARY_SUPPLEMENT

Polydextrose

PDX will be started 2 weeks before TIPS and taken daily for a 6 month period after TIPS.

Locations (1)

Toulouse University Hospital

Toulouse, France