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MRI in High-Grade Glioma Patients Undergoing Chemoradiation
Sponsor: Wake Forest University Health Sciences
Summary
The purpose of this research study is to see if investigators can predict how brain functioning changes after radiation treatment based on PET scans and blood tests. Most participants experience at least mild decreases in their memory or attention after radiation therapy. Investigators hope that PET scans, optional lumbar puncture, and blood tests might help investigators predict who might have larger changes in their brain function after radiation.
Official title: A Feasibility Study of Interim PET-MRI in High-grade Glioma Patients Undergoing Chemoradiation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2022-09-02
Completion Date
2027-12
Last Updated
2026-08-17
Healthy Volunteers
No
Conditions
Interventions
PET-MRI Brain Scan
Before starting radiation, participants will have a PET scan and MRI scan of the brain. After 2 to 3 weeks of radiation treatments, participants will have a repeat PET scan. Then, at 1 month and 3 to 4 months after radiation, participants will have another MRI scan.
Blood draw
Blood draws will be taken at baseline, one month after radiation treatment, and 3 to 4 months after radiation treatment.
Memory testing
3 sessions with simple tests to evaluate how the brain is working. These tests primarily check things like memory, attention, and thought process. The whole set of tests will take 1 hour each time at baseline, one month after radiation, and 3 to 4 months after radiation.
Optional lumbar puncture for cerebrospinal fluid collection
Participants that consent for cerebrospinal fluid collection will have between 6 to 20 ml of cerebrospinal collected at baseline.
Locations (1)
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States