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WithHolding Enteral Feeds Around Blood Transfusion (International)
Sponsor: IWK Health Centre
Summary
The WHEAT International trial is a comparative effectiveness trial exploring whether withholding enteral feeds around the time of blood transfusion in very premature infants (\<30 weeks) will reduce the occurrence of Necrotizing Enterocolitis (NEC). Currently both continued feeding and withholding feeding are approved care practices. The current study will randomize infants from Neonatal Intensive Care Units (NICUs) across Canada and the United Kingdom (UK) into one of the two care approaches (withholding or continued feeds) to determine if any significant outcomes are found.
Official title: The WHEAT International Trial: WithHolding Enteral Feeds Around Red Cell Transfusion to Prevent Necrotizing Enterocolitis in Preterm Neonates: an International, Multi-centre, Randomized Controlled Trial
Key Details
Gender
All
Age Range
Any - 30 Weeks
Study Type
INTERVENTIONAL
Enrollment
4333
Start Date
2022-01-28
Completion Date
2027-03-31
Last Updated
2025-11-24
Healthy Volunteers
No
Conditions
Interventions
Withholding feeds around transfusion
Withholding enteral feeds for preterm infants (\<30 weeks) around the time of blood transfusions to determine if any impact on the development and/or severity of Necrotizing Enterocolitis.
Continued feeds around transfusion
Continued enteral feeds
Locations (1)
IWK Health
Halifax, Nova Scotia, Canada