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WithHolding Enteral Feeds Around Blood Transfusion (International)
Sponsor: IWK Health Centre
Summary
The WHEAT International trial is a comparative effectiveness trial exploring whether withholding enteral feeds around the time of blood transfusion in very premature infants (\<30 weeks) will reduce the occurrence of Necrotizing Enterocolitis (NEC). Currently both continued feeding and withholding feeding are approved care practices. The current study will randomize infants from Neonatal Intensive Care Units (NICUs) across Canada and the United Kingdom (UK) into one of the two care approaches (withholding or continued feeds) to determine if any significant outcomes are found.
Official title: The WHEAT International Trial: WithHolding Enteral Feeds Around Red Cell Transfusion to Prevent Necrotizing Enterocolitis in Preterm Neonates: an International, Multi-centre, Randomized Controlled Trial
Key Details
Gender
All
Age Range
Any - 30 Weeks
Study Type
INTERVENTIONAL
Enrollment
4333
Start Date
2022-01-28
Completion Date
2027-03-31
Last Updated
2026-04-24
Healthy Volunteers
No
Conditions
Interventions
Withholding feeds around transfusion
Withholding enteral feeds for preterm infants (\<30 weeks) around the time of blood transfusions to determine if any impact on the development and/or severity of Necrotizing Enterocolitis.
Continued feeds around transfusion
Continued enteral feeds
Locations (40)
IWK Health
Halifax, Nova Scotia, Canada
Norfolk & Norwich University Hospitals NHS Foundation Trust (Norfolk & Norwich University Hospital)
Norwich, England, United Kingdom
The Hillingdon Hospitals NHS Foundation Trust (Hillingdon Hospital)
Hillingdon, UK, United Kingdom
Barts Health NHS Trust (3 Hospitals: Royal London Hospital, Whipps Cross Hospital, Newham General Hospital)
London, UK, United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust (Chelsea and Westminster Hospital)
London, UK, United Kingdom
Imperial College Healthcare NHS Trust (2 Hospitals: St Mary's Hospital & Queen Charlotte's and Chelsea Hospital)
London, UK, United Kingdom
Bedfordshire Hospitals NHS Foundation Trust (Luton & Dunstable University Hospital)
Luton, UK, United Kingdom
East Kent University Hospitals NHS Foundation Trust (William Harvey Hospital)
Ashford, United Kingdom
Buckinghamshire Healthcare NHS Trust (Stoke Mandeville Hospital)
Aylesbury, United Kingdom
Barnsley Hospital NHS Foundation Trust
Barnsley, United Kingdom
Birmingham Women's and Children's NHS Foundation Trust (Birmingham Women's Hospital NICU)
Birmingham, United Kingdom
University Hospitals Birmingham NHS Trust (2 Hospitals: Heartland's Hospital & Good Hope Hospital)
Birmingham, United Kingdom
Bradford Teaching Hospitals NHS Foundation Trust (Bradford Royal Infirmary)
Bradford, United Kingdom
North Bristol NHS Trust (Southmead Hospital)
Bristol, United Kingdom
East and North Essex NHS Foundation Trust - Colchester Hospital
Colchester, United Kingdom
University Hospital Coventry & Warwickshire NHS Trust (University Hospital Coventry)
Coventry, United Kingdom
University Hospitals of Derby and Burton NHS Trust (Royal Derby Hospital)
Derby, United Kingdom
NHS Tayside (Ninewells Hospital)
Dundee, United Kingdom
Medway Hospital NHS Foundation Trust (Oliver Fisher Neonatal Unit, Medway Maritime Hospital)
Gillingham, United Kingdom
Gloucestershire Hospitals NHS Foundation Trust (Gloucestershire Royal Hospital)
Gloucester, United Kingdom
Calderdale & Huddersfield NHS Foundation Trust (Calderdale Royal Hospital)
Halifax, United Kingdom
East and North Essex NHS Foundation Trust - Ipswich Hospital
Ipswich, United Kingdom
Leeds Teaching Hospitals NHS Trust (Leeds General Infirmary & St James' University Hospital)
Leeds, United Kingdom
University Hospitals of Leicester NHS Trust (Leicester Royal Infirmary)
Leicester, United Kingdom
Liverpool Women's Hospital NHS Foundation Trust (Liverpool Women's Hospital)
Liverpool, United Kingdom
North West London NHS Trust (Northwick Park Hospital)
London, United Kingdom
Manchester University NHS Foundation Trust (2 Hospitals: St Mary's Hospital - Oxford Road, North Manchester General)
Manchester, United Kingdom
Manchester University NHS Foundation Trust (Wythenshawe)
Manchester, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust (Royal Victoria Infirmary)
Newcastle upon Tyne, United Kingdom
Nottingham University Hospitals NHS Trust (2 Hospitals: City Hospital, Queen's Medical Centre)
Nottingham, United Kingdom
Oxford University Hospitals NHS FT (John Radcliffe Hospital)
Oxford, United Kingdom
North West Anglia NHS Trust (Peterborough City Hospital)
Peterborough, United Kingdom
Portsmouth University Hospitals NHS Trust (Queen Alexandra Hospital)
Portsmouth, United Kingdom
Lancashire Teaching Hospitals NHS Foundation Trust (Royal Preston Hospital)
Preston, United Kingdom
The Shrewsbury & Telford Hospitals NHS Trust (Royal Shrewsbury Hospital)
Shrewsbury, United Kingdom
University Hospital Southampton NHS Foundation Trust (Southampton General Hospital)
Southampton, United Kingdom
Betsi Cadwaladr University Health Board (Glan Cwyd Hospital)
Wales, United Kingdom
Walsall Healthcare NHS Trust (Walsall Manor Hospital)
Walsall, United Kingdom
West Hertfordshire Hospitals NHS Trust (Watford General Hospital)
Watford, United Kingdom
Royal Wolverhampton NHS Trust (New Cross Hospital)
Wolverhampton, United Kingdom