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Cortical Contributions to FFR: Post-Op Outcomes
Sponsor: University of Pittsburgh
Summary
The purpose of this study is to better understand cortical contributions of the human temporal lobe to the frequency-following response. Frequency-following responses (FFR) are electrophysiological recordings that reflect phase-locked activity of neural ensembles in the auditory pathway and are used as an indicator of the integrity of supra-threshold speech processing. FFR was first studied in subcortical areas, but recent consensus in the literature supports the notion that it is an integrated response between subcortical and cortical neural populations. The proposed study aims to deconstruct the role of the cortex in generating and modulating the FFR. The research team will build a novel computational model of FFR mechanisms and use EEG recordings from participants who have undergone resection of lesions in Heschl's gyrus to validate model predictions.
Official title: Cortical Contributions to Frequency-Following Response Generation and Modulation; Post-Operative Outcomes
Key Details
Gender
All
Age Range
13 Years - 25 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2023-02-14
Completion Date
2030-01-01
Last Updated
2026-01-15
Healthy Volunteers
No
Conditions
Interventions
Speech sound stimulation
Participants will listen to repetitive speech sound stimuli, presented through headphones, which will induce a neural response (frequency-following response) to be measured via electroencephalography and pupillometry
Locations (1)
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States