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Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia
Sponsor: University of British Columbia
Summary
ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and will impact patient care and outcomes. The study will recruit patients admitted to hospital with an acute coronary syndrome, and research-based genetic testing will be conducted for known FH-causing genetic variants. The results will be returned to the patients' treating physicians. The primary endpoint will be the number of patients with a new diagnosis of definite FH. The secondary endpoints will be the proportion of patients who undergo intensification of lipid-lowering therapy, the lowest LDL cholesterol level achieved, and the proportion of patients reaching guideline recommended lipid targets in the 15 months after the index acute coronary syndrome.
Official title: The Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia (ACCURATE) Study
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2022-01-01
Completion Date
2025-08-29
Last Updated
2026-05-01
Healthy Volunteers
No
Conditions
Interventions
Research-based genetic test for Familial Hypercholesterolemia
Next-generation targeted sequencing assay to identify DNA variants in genes known to cause Familial Hypercholesterolemia
Locations (2)
Vancouver General Hospital
Vancouver, British Columbia, Canada
St.Pauls Hospital
Vancouver, British Columbia, Canada