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Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
Sponsor: University of Missouri-Columbia
Summary
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2023-03-14
Completion Date
2026-06-30
Last Updated
2025-05-29
Healthy Volunteers
Yes
Conditions
Interventions
Propranolol Hydrochloride
Regional forearm blockade of β-adrenergic receptors at 20 mcg/dL/min via brachial artery catheter during normoxia and hypoxia exposures
Isoproterenol
Dose response (1, 3, 6, and 12 ng/dL/min) regional infusion to assess β-adrenergic receptor responsiveness
Phentolamine Mesylate
This infusion will be for 10 min before baseline measurement (12 mcg/dL/min) and continue the infusion at a maintenance rate (5 mcg/dL/min).
Norepinephrine
Regional forearm infusion at 8 ng/dL/min via brachial artery catheter during normoxia and hypoxia exposures
Locations (1)
University of Missouri
Columbia, Missouri, United States