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Platelet Rich Plasma for Uterine Scar
Sponsor: The University of Texas Health Science Center, Houston
Summary
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing. Platelet-rich plasma (PRP), a modification of fibrin glue made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring wound healing. PRP is obtained from a sample of patients' blood drawn at the time of treatment. As the rate of cesarean deliveries has been rising, long-term adverse sequelae due to uterine scar defects have been increasing. PRP might be a simple preventive treatment that potentially can reduce morbidity following cesarean deliveries.
Official title: Platelet Rich Plasma for the Treatment of Uterine Scar
Key Details
Gender
FEMALE
Age Range
18 Years - 52 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-07-19
Completion Date
2028-07-01
Last Updated
2025-08-26
Healthy Volunteers
Yes
Interventions
Platelet Rich Plasma
Injection of 5cc of PRP preparation at the myometrium around the uterine incision after it has been sutured.
Placebo
Injection of 5cc of 0.9% Normal Saline at the myometrium around the uterine incision after it has been sutured.
Locations (1)
Sheba Medical Center
Ramat Gan, Center, Israel