Clinical Research Directory
Browse clinical research sites, groups, and studies.
Impact of Lp299v on Vascular Function in Patients With PASC
Sponsor: Medical College of Wisconsin
Summary
Emerging data show that SARS-CoV-2 infection causes gut microbiome changes strongly associated with Post-Acute Sequelae of SARS-CoV-2 (PASC). The investigators and others have established that an orally ingested probiotic (Lactobacillus plantarum 299v, Lp299v) reduces circulating levels of cell-free mitochondrial DNA (cf-mtDNA), decreases toll-like receptor 9 (TLR9) activation \[and downstream interleukin (IL-6)\], and improves micro- and macrovascular (brachial artery) endothelial dysfunction \[as measured by flow-mediated dilation (FMD%)\] in humans. Recently published data also report impaired brachial FMD% and increased vascular stiffness post-SARS-CoV-2 infection. Based on these data, the investigators hypothesize that supplementation with Lp299v will attenuate SARS-CoV-2 associated endothelial dysfunction by reducing cf-mtDNA, TLR9 activation, and inflammation.
Key Details
Gender
All
Age Range
18 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2022-04-29
Completion Date
2026-03-31
Last Updated
2025-04-27
Healthy Volunteers
No
Conditions
Interventions
Lactobacillus Plantarum 299v Freeze Dried Capsule
The intervention is a probiotic lactobacillus that is contained in food products in the US
Freeze Dried Potato Starch Capsule
The intervention is potato starch that is freeze dried designed to mimic the lp299v capsule.
Locations (1)
Medical College of Wisconsin
Milwaukee, Wisconsin, United States