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Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules
Sponsor: City of Hope Medical Center
Summary
This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.
Official title: Evaluation of DNA Methylation Signatures in Diagnosis and Management of Thyroid Nodules
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1450
Start Date
2021-10-22
Completion Date
2026-10-22
Last Updated
2026-02-23
Healthy Volunteers
No
Conditions
Interventions
Diagnostic Procedure
Analysis via DDMS-2
Electronic Health Record Review
Review of medical records
Needle Biopsy
Undergo needle biopsy
Locations (1)
City of Hope Medical Center
Duarte, California, United States