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The PURI-HF (Air Purifiers on Heart Failure) Trial
Sponsor: NYU Langone Health
Summary
Indoor air pollution and fine mode particulate matter with an aerodynamic diameter smaller than 2.5 micrometers (PM2.5) is a major contributor to global morbidity and mortality, particularly due to cardiovascular disease. This project aims to demonstrate the efficacy, feasibility and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India. The findings from the project will add to existing knowledge of innovative and scalable strategies to improve environmental and cardiovascular health worldwide. The overall objective of this study is to demonstrate the efficacy, feasibility, and effectiveness of portable air filters in improving indoor PM2.5 levels and improving functional capacity of heart failure patients with reduced ejection fraction in India.
Official title: Effectiveness of Indoor Air Purifiers on Heart Failure Outcomes
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
255
Start Date
2024-03-06
Completion Date
2028-04-30
Last Updated
2026-01-29
Healthy Volunteers
No
Conditions
Interventions
AirOk Air Purifier
The AirOk purifier nests on a locally developed patented technology that combines HEPA (grade H12) and a novel EGAPA (Effective Granular Adsorbent Particulate Arrestor) to reduce indoor air pollution. The HEPA filter removes all particulate matter up to 0.3 µm in aerodynamic diameter, and the dual stratified EGAPA filter removes other pollutants such as sulfur, nitrous oxide, carbon oxide, volatile organic compounds, allergens, and mold.
Placebo Air Filter
Participants in the placebo arm will receive an air purifier with only the EGAPA filter.
Locations (3)
Centre for Chronic Disease Control (CCDC)
Thiruvananthapuram, Kerala, India
All India Institute of Medical Sciences (AIIMS)
Delhi, Punjab, India
Public Health Foundation of India (PHFI)
Ludhiana, Punjab, India