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mTOR as Mediator of Insulin Sensitivity Study
Sponsor: University of Copenhagen
Summary
The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. This will be investigated in young healthy male subjects by administering the pharmacological mTOR inhibitor Rapamycin in a crossover blinded experimental setup known to enhance muscle insulin sensitivity following one-legged knee-extensor exercise.
Official title: Mechanistic Target of Rapamycin (mTOR) as Mediator of Exercise-induced Insulin Sensitivity Study
Key Details
Gender
MALE
Age Range
22 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2022-02-10
Completion Date
2029-06
Last Updated
2024-05-16
Healthy Volunteers
Yes
Conditions
Interventions
Exercise
1 hour of one-legged knee-extensor exercise followed by 4 hours of rest
Insulin infusion
2 hours of Euglycemic Hyperinsulinemic Clamp
Placebo
Administration of 800 mg of calcium tablets
Rapamycin
Administration of 16 mg of Rapamycin tablets
Locations (1)
University of Copenhagen
Copenhagen, Denmark