Clinical Research Directory

Inclusion Criteria: * 1.Age between 18 and 75 years 2.The primary gastric lesion was histopathologically diagnosed as middle and upper gastric adenocarcinoma (papillary adenocarcinoma PAP, tubular adenocarcinoma TUB, mucinous adenocarcinoma MUC, signed-ring cell carcinoma SIG, poorly differentiated adenocarcinoma POR) by endoscopic biopsy. 3.Preoperative clinical stages were CT2-4A、 N-/+、and M0 (according to AJCC-8th TNM tumor staging) 4.Excepting to perform radical total gastrectomy and D2 lymph node dissection can achieve R0 resection. 5.American Society of Anesthesiology (ASA) score class I, II, or III 6.Written informed consent Exclusion Criteria: 1. Preoperative examination suggested disease staging cT1, N-/+, and M0 (according to AJCC-8th TNM tumor staging ) 2. Women during pregnancy or breast-feeding 3. Severe mental disorder 4. History of previous upper abdominal surgery (except laparoscopic cholecystectomy) 5. History of previous gastrectomy(except for ESD/EMR for gastric cancer ) 6. Enlarged or bulky regional lymph node over 3 cm by preoperative imaging 7. History of other malignant disease within the past five years 8. History of previous neoadjuvant chemotherapy or radiotherapy 9. History of unstable angina or myocardial infarction within past six months 10. History of cerebrovascular accident within past six months 11. History of continuous systematic administration of corticosteroids within one month 12. Requirement for simultaneous surgery for other disease(except laparoscopic cholecystectomy) 13. Emergency surgery due to complication (bleeding, obstruction or perforation) caused by gastric cancer 14. FEV1 (forced expiratory volume in one second)\<50% of predicted values