Clinical Research Directory

Inclusion Criteria: * Aged ≥18 years old, male or female; * Conform to the diagnostic criteria of chemotherapy-induced thrombocytopenia (CIT); Ineffective after repeated treatment with rhTPO or IL-11； * Stop radiotherapy or chemotherapy for more than 1 month; * Platelet counts \<30 ×10\^9/L, and bleeding tendency; * Estimated survival period ≥ 6 months； * People who are willing to sign the informed consent voluntarily and follow the research program. * Liver and kidney function\<1.5×upper limit of normal, qualified for physical examination； * Subject is practicing an acceptable method of contraception. Women of childbearing potential must have a negative serum pregnancy test in the whole study; Exclusion Criteria: * Those with uncontrollable primary diseases of important organs, such as extensive metastasis of malignant tumors, liver failure, heart failure, kidney failure and other diseases； * Patients with poor compliance; * Positive serology for HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), and/or hepatitis D virus (HDV), Syphilis; Positive for Epstein-Barr Virus DNA, Cytomegalovirus DNA; * Accompanied by extensive and severe bleeding, such as hemoptysis, upper gastrointestinal bleeding, intracranial hemorrhage, etc. * There is currently a heart disease requiring treatment or a poorly controlled hypertension judged by the investigator； * Patients with thrombotic diseases such as pulmonary embolism, thrombosis, and atherosclerosis； * Those who have received allogeneic stem cell transplantation or organ transplantation in the past； * Patients with mental disorders who cannot normally obtain informed consent and undergo trials and follow-up； * Patients whose toxic symptoms caused by treatment before participating in the trial have not disappeared； * Other serious diseases that may restrict participants from participating in this trial (such as diabetes; severe heart failure; myocardial obstruction or unstable arrhythmia or unstable angina in the past 6 months; gastric ulcers; mobility Autoimmune diseases, etc.)； * Patients with sepsis or patients with other irregular bleeding； * Patients taking antiplatelet drugs at the same time； * Pregnant women, suspected pregnancy (a positive pregnancy test for human chorionic gonadotropin in urine at screening) and breastfeeding patients； * Pre-existing cardiac disease, including congestive heart failure of New York Heart Association \[NYHA\] Grade III/IV, arrhythmia requiring treatment or myocardial infarction within the last 6 months. No arrhythmia known to increase the risk of thrombotic events (e.g. atrial fibrillation), or patients with a QT \>450msec or QTc \> 480 for patients with a Bundle Branch Block; * Researchers believe that patients should not participate in the test of any other condition.