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Imaging Sodium and Lymphatics in Lymphedema
Sponsor: University of Virginia
Summary
Recent evidence supports lymphatic regulation of tissue sodium handling, however fundamental gaps persist in knowledge regarding the role of lymphatics in human diseases of sodium dysregulation. The goal of this work is to apply novel, noninvasive imaging tools to measure relationships between lymphatic function and tissue sodium in patients with well-characterized lymphedema. Findings are intended to inform mechanisms of lymphatic clearance of tissue sodium, and provide novel imaging biomarkers of lymphedema progression and treatment response.
Key Details
Gender
FEMALE
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
75
Start Date
2021-10-10
Completion Date
2025-12
Last Updated
2025-04-27
Healthy Volunteers
No
Interventions
Complete decongestive therapy
The investigators will identify participants undergoing clinically-indicated interventions that they are already receiving for their routine clinical management (complete decongestive physical therapy). They will make no evaluation of the efficacy of these procedures, but rather will test fundamental hypotheses regarding lymphatic clearance of tissue sodium.
Standard imaging protocol
The standard imaging protocol entails noninvasive magnetic resonance imaging techniques including sodium and lymphatic angiography.
Locations (1)
University of Virginia
Charlottesville, Virginia, United States