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Individual Risk Profiles for Adverse Drug Reactions in Geriatric Patients
Sponsor: RWTH Aachen University
Summary
This project will generate a prospective cohort of geriatric patients with polypharmacy which will be characterized for vulnerability profiles of adverse drug reactions.
Official title: Individual Patient Risk Profiles for Adverse Drug Reactions: Establishing a Consecutive Research Cohort in an Interdisciplinary Polypharmacy Consultation Service of a Geriatric University Outpatient Department
Key Details
Gender
All
Age Range
70 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2000
Start Date
2022-07
Completion Date
2032-02
Last Updated
2022-06-23
Healthy Volunteers
No
Conditions
Interventions
Pharmacogenomic testing of a panel of important pharmacogenes to detect genetic variants and evaluate the association between genetically predicted and measured drug metabolism
All planned interventions are explorative analyses of biological and genetic risk profiles that can contribute to patients' individual risk for adverse drug reactions, i.e. due to variability in drug metabolism
Adverse Drug Reaction detection
During appointments in the university outpatient clinic, patients will undergo a comprehensive adverse drug reaction (ADR) assessment based on an ADR diary they were handed at enrolment
Falls Efficacy Scale International (FES-I)
The FES-I wil be obtained to estimate fear of falling