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Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance
Sponsor: Poznan University of Physical Education
Summary
The primary aims of the current study: * using L-carnitine supplementation modulate the level of plasma trimethylamine N-oxide to assess its effect on circulating cytokines related to diabetes and metabolic syndrome; * using simulated night-shift work intervention as a stress factor, explore the effect of circulating metabolites on insulin sensitivity The secondary aim is to evaluate the effect of carnitine supplementation on gut microbiome composition.
Official title: The Role of Gut Microbiota Metabolite, Trimethylamine N-oxide, in the Insulin Resistance Development
Key Details
Gender
All
Age Range
20 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2022-02-07
Completion Date
2027-05-31
Last Updated
2025-10-03
Healthy Volunteers
Yes
Conditions
Interventions
L-carnitine
L-carnitine-L-tartrate
L-leucine
L-leucine
Change of the circadian cycle
Reducing sleep at night for four consecutive days (enabling sleep between 8:00 and 17:00)
Locations (1)
Akademia Wychowania Fizycznego
Poznan, Poland