Clinical Research Directory

In order to be eligible to participate in this study, a subject must meet the following criteria: * Aged ≥ 18 years * Capable of understanding and signing informed consent. Inclusion criteria for the CAS study are patients diagnosed with a valvular congenital aortic stenosis. Two groups of patients will be included: * Patients with a prior aortic valve replacement (AVR) * Patients without a prior AVR and with an aortic jet velocity ≥ 2.5 m/s. Exclusion Criteria: * Patients with severe aortic regurgitation * Presence of any of the following contra-indications for MRI * Contra-indication to gadolinium based contrast media (eGFR \<30 ml/min or contrast allergy) * Other contra-indications such as presence of pacemaker/implantable cardioverter defibrillator, severe claustrophobia or pregnancy * Patients known with or previously treated because of aortic coarctation. * Patients known with genetic syndromes or connective tissue disorders