Clinical Research Directory
Browse clinical research sites, groups, and studies.
Timing of Necrosectomy After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)
Sponsor: Chinese University of Hong Kong
Summary
Walled-off pancreatic necrosis (WON) is associated with a mortality of 20-30%. The current evidence supports a minimally invasive drainage approach to infected WON. The current suggested approach in international guidelines is the endoscopic step-up approach. However, recent evidence from large national cohorts support the use of direct endoscopic necrosectomy (DEN) at the time of stent placement, resulting in earlier resolution of WON and less number of necrosectomies. This study aims to investigate the clinical outcomes of the DEN versus the step-up approach for necrosectomy after endoscopic drainage of WON.
Official title: Direct Endoscopic Necrosectomy Versus Endoscopic Step-up Approach After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
108
Start Date
2022-02-01
Completion Date
2026-06-30
Last Updated
2022-03-09
Healthy Volunteers
No
Conditions
Interventions
Endoscopic necrosectomy with step up approach
Endoscopic necrosectomy will be performed with a forward-viewing gastroscope into the WON cavity. Debridement of necrotic tissue will be performed with irrigation and/or mechanical removal with endoscopic instruments. For this arm, step up approach will be adopted.
Endoscopic necrosectomy with direct approach
Endoscopic necrosectomy will be performed with a forward-viewing gastroscope into the WON cavity. Debridement of necrotic tissue will be performed with irrigation and/or mechanical removal with endoscopic instruments. For this arm, the direct approach will be adopted.
Locations (9)
Royal Adelaide Hospital
Adelaide, Australia
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Medanta Institute Of Digestive & Hepatobiliary Sciences
Haryāna, India
Asian Institute of Gastroenterology
Hyderabad, India
Deenanath Mangeshkar Hospital & Research Centre
Pune, India
Asan Medical Centre
Asan, South Korea
SoonChunHyang University School of Medicine
Asan, South Korea
Hospital Universitario Rio Hortega
Valladolid, Spain
King Chulalongkorn Memorial Hospital
Bangkok, Thailand