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Prodromal Parkinsonian Features in GBA1 Mutation Carriers
Sponsor: Shaare Zedek Medical Center
Summary
Objective of the trial. To define a sub-population which is at increased risk of developing Parkinson, beyond the fact of carrying Gaucher; in this sub-population the investigators shall conduct a comprehensive evaluation that includes a variety of non-invasive tests, whose purpose is to evaluate the state of the pre- Parkinson's disease signs, signs which can appear, even twenty years before the appearance of the disease, and also to compare them to a group of diagnosed Gaucher patients and a group of healthy people who are not carriers of Gaucher disease. A group of those carriers will be available for trial or for treatment, if there will be a medicine for the prevention of the development of Parkinson, obtainable.
Key Details
Gender
All
Age Range
40 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2017-05-16
Completion Date
2030-12-31
Last Updated
2026-04-29
Healthy Volunteers
Yes
Conditions
Interventions
The investigators aim to identify prodromal PD in a cohort of carriers of Gaucher disease.
Tests to help identify prodromal PD in a cohort of carriers of Gaucher disease
Locations (1)
Michal Becker- Cohen
Jerusalem, Please Select..., Israel