Clinical Research Directory

Inclusion Criteria: * Detectable CAC (Agatson score \>=10) assessed by Cardiac Computed Tomography (CT) scan in the Inter99 20-year follow-up study Exclusion Criteria: * Manifest CVD (prior cerebral infarct, prior myocardial infarct, prior percutaneous coronary intervention or prior coronary artery bypass surgery) * Noise on the CT scan, which complicates an accurate assessment of CAC and interpretation of the CT scan. An example is a pacemaker * Current treatment with Vitamin K antagonist (VKA). * History of coagulation disorders (hemophilia, von Willebrand disease, sickle cell anemia) * Active malignant disease (ongoing treatment) * Previous surgical removal of the thyroid gland, or one or more of the parathyroid glands * Regular use of vitamin K supplements other than trial tablets * Pregnancy or breastfeeding