Clinical Research Directory
Browse clinical research sites, groups, and studies.
Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment
Sponsor: AstraZeneca
Summary
Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.
Official title: A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated, MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON).
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
345
Start Date
2022-08-03
Completion Date
2026-11-23
Last Updated
2026-04-06
Healthy Volunteers
No
Conditions
Interventions
Savolitinib
300 mg savolitinib (3 × 100 mg tablets twice daily) Administrative route : oral
Osimertinib
80 mg osimertinib (1 × 80 mg tablet once daily) Administrative route : oral
Pemetrexed
Pemetrexed (500 mg/m2) Administrative route : IV infusion
Cisplatin
Cisplatin (75 mg/m2) Administrative route : IV infusion
Carboplatin
Carboplatin (AUC5) Administrative route : IV infusion
Locations (226)
Research Site
Orlando, Florida, United States
Research Site
Honolulu, Hawaii, United States
Research Site
New Brunswick, New Jersey, United States
Research Site
New York, New York, United States
Research Site
Nashville, Tennessee, United States
Research Site
Buenos Aires, Argentina
Research Site
CABA, Argentina
Research Site
Florida, Argentina
Research Site
La Rioja, Argentina
Research Site
Rosario, Argentina
Research Site
Rosario, Argentina
Research Site
San Miguel de Tucumán, Argentina
Research Site
Viedma, Argentina
Research Site
Clayton, Australia
Research Site
Fremantle, Australia
Research Site
Liverpool, Australia
Research Site
Southport, Australia
Research Site
Waratah NSW, Australia
Research Site
Westmead, Australia
Research Site
Salzburg, Austria
Research Site
Brussels, Belgium
Research Site
Edegem, Belgium
Research Site
Ghent, Belgium
Research Site
Hasselt, Belgium
Research Site
Mons, Belgium
Research Site
Roeselare, Belgium
Research Site
Sint-Niklaas, Belgium
Research Site
Belo Horizonte, Brazil
Research Site
Brasília, Brazil
Research Site
Cachoeiro de Itapemirim, Brazil
Research Site
Curitiba, Brazil
Research Site
Ijuí, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Rio de Janeiro, Brazil
Research Site
Rio de Janeiro, Brazil
Research Site
Salvador, Brazil
Research Site
Salvador, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
Vitória, Brazil
Research Site
Pleven, Bulgaria
Research Site
Toronto, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Santiago, Chile
Research Site
Baoding, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Bengbu, China
Research Site
Changchun, China
Research Site
Changsha, China
Research Site
Changsha, China
Research Site
Chengdu, China
Research Site
Chongqing, China
Research Site
Fuzhou, China
Research Site
Fuzhou, China
Research Site
Hangzhou, China
Research Site
Harbin, China
Research Site
Hefei, China
Research Site
Jinan, China
Research Site
Linyi, China
Research Site
Nanchang, China
Research Site
Qingdao, China
Research Site
Shanghai, China
Research Site
Shenyang, China
Research Site
Shenzhen, China
Research Site
Wuhan, China
Research Site
Wuhan, China
Research Site
Xi'an, China
Research Site
Xi'an, China
Research Site
Xiangfan, China
Research Site
Yichang, China
Research Site
Zhengzhou, China
Research Site
Bobigny, France
Research Site
Brest, France
Research Site
Créteil, France
Research Site
Dijon, France
Research Site
Marseille, France
Research Site
Paris, France
Research Site
Poitiers, France
Research Site
Rennes, France
Research Site
Rouen, France
Research Site
Saint-Herblain, France
Research Site
Saint-Quentin, France
Research Site
Strasbourg, France
Research Site
Suresnes, France
Research Site
Berlin, Germany
Research Site
Chemnitz, Germany
Research Site
Frankfurt A. Main, Germany
Research Site
Gauting, Germany
Research Site
Immenhausen, Germany
Research Site
Löwenstein, Germany
Research Site
München, Germany
Research Site
Münster, Germany
Research Site
Wangen, Germany
Research Site
Athens, Greece
Research Site
Athens, Greece
Research Site
Chaïdári, Greece
Research Site
Heraklion, Greece
Research Site
Larissa, Greece
Research Site
Rio, Greece
Research Site
Thessaloniki, Greece
Research Site
Thessaloniki, Greece
Research Site
Hong Kong, Hong Kong
Research Site
Kowloon, Hong Kong
Research Site
Afula, Israel
Research Site
Ashdod, Israel
Research Site
Be’er Ya‘aqov, Israel
Research Site
Hadera, Israel
Research Site
Jerusalem, Israel
Research Site
Tel Aviv, Israel
Research Site
Avellino, Italy
Research Site
Aviano, Italy
Research Site
Catania, Italy
Research Site
Meldola, Italy
Research Site
Milan, Italy
Research Site
Milan, Italy
Research Site
Modena, Italy
Research Site
Monserrato, Italy
Research Site
Naples, Italy
Research Site
Orbassano, Italy
Research Site
Padova, Italy
Research Site
Parma, Italy
Research Site
Perugia, Italy
Research Site
Peschiera del Garda, Italy
Research Site
Roma, Italy
Research Site
Roma, Italy
Research Site
Treviso, Italy
Research Site
Bunkyō City, Japan
Research Site
Chūōku, Japan
Research Site
Fukuoka, Japan
Research Site
Hirosaki-shi, Japan
Research Site
Hiroshima, Japan
Research Site
Iwakuni-shi, Japan
Research Site
Kanazawa, Japan
Research Site
Kashiwa, Japan
Research Site
Kobe, Japan
Research Site
Kobe, Japan
Research Site
Kumamoto, Japan
Research Site
Kurume-shi, Japan
Research Site
Nagasaki, Japan
Research Site
Okayama, Japan
Research Site
Osaka, Japan
Research Site
Osakasayama-shi, Japan
Research Site
Sakaishi, Japan
Research Site
Sapporo, Japan
Research Site
Sapporo, Japan
Research Site
Sendai, Japan
Research Site
Sunto-gun, Japan
Research Site
Utsunomiya, Japan
Research Site
Wakayama, Japan
Research Site
Yokohama, Japan
Research Site
Kota Bharu, Malaysia
Research Site
Kuala Lumpur, Malaysia
Research Site
Petaling Jaya, Malaysia
Research Site
Pulau Pinang, Malaysia
Research Site
Sabak Bernam, Malaysia
Research Site
Bacolod, Philippines
Research Site
Davao City, Philippines
Research Site
Manila, Philippines
Research Site
Quezon City, Philippines
Research Site
Quezon City, Philippines
Research Site
San Juan City, Philippines
Research Site
Lodz, Poland
Research Site
Olsztyn, Poland
Research Site
Singapore, Singapore
Research Site
Singapore, Singapore
Research Site
Goyang-si, South Korea
Research Site
Gyeonggi-do, South Korea
Research Site
Jinju, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Suwon, South Korea
Research Site
Badajoz, Spain
Research Site
Badalona, Spain
Research Site
Barcelona, Spain
Research Site
Barcelona, Spain
Research Site
Córdoba, Spain
Research Site
Girona, Spain
Research Site
Madrid, Spain
Research Site
Madrid, Spain
Research Site
Majadahonda, Spain
Research Site
Málaga, Spain
Research Site
Pontevedra, Spain
Research Site
Sabadell, Spain
Research Site
Seville, Spain
Research Site
Valencia, Spain
Research Site
Zaragoza, Spain
Research Site
Baden, Switzerland
Research Site
Zurich, Switzerland
Research Site
Chiayi City, Taiwan
Research Site
Hsinchu, Taiwan
Research Site
Kaohsiung City, Taiwan
Research Site
Liuying, Taiwan
Research Site
Taichung, Taiwan
Research Site
Taichung, Taiwan
Research Site
Taipei, Taiwan
Research Site
Taipei, Taiwan
Research Site
Taipei, Taiwan
Research Site
Bangkok, Thailand
Research Site
Bangkok, Thailand
Research Site
Chanthaburi, Thailand
Research Site
Chiang Mai, Thailand
Research Site
Dusit, Thailand
Research Site
Hat Yai, Thailand
Research Site
Muang, Thailand
Research Site
Adana, Turkey (Türkiye)
Research Site
Ankara, Turkey (Türkiye)
Research Site
Edirne, Turkey (Türkiye)
Research Site
Istanbul, Turkey (Türkiye)
Research Site
Istanbul, Turkey (Türkiye)
Research Site
Izmir, Turkey (Türkiye)
Research Site
London, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
Wolverhampton, United Kingdom
Research Site
Can Tho, Vietnam
Research Site
Hanoi, Vietnam
Research Site
Hanoi, Vietnam
Research Site
Ho Chi Minh City, Vietnam
Research Site
Ho Chi Minh City, Vietnam