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His-Bundle Corrective Pacing in Heart Failure
Sponsor: University of Rochester
Summary
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2022-12-02
Completion Date
2028-07-01
Last Updated
2026-02-09
Healthy Volunteers
No
Interventions
His-CRT implantation
The pathophysiological process is utilized in His-Bundle corrective pacing, resulting in a faster and more homogeneous activation of the heart pacing directly via the intrinsic conduction system of the heart accompanied by a right atrial endocardial lead and a right ventricular endocardial lead.
BIV-CRT implantation
Biventricular cardiac resynchronization therapy has been shown to improve outcomes by delivering synchronized electrical stimuli to the right and left ventricles utilizing an an endocardial right atrial lead, an endocardial right ventricular lead, and an epicardial left ventricular lead implanted in a branch of the coronary sinus.
Locations (14)
University of Arizona
Phoenix, Arizona, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
University of South Florida
Tampa, Florida, United States
Northwestern Memorial Hospital
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Valley Health System
Ridgewood, New Jersey, United States
Weill Cornell Medical College
New York, New York, United States
Mount Sinai Hospital
New York, New York, United States
Mission Health
Asheville, North Carolina, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Geisinger Wyoming Valley
Wilkes-Barre, Pennsylvania, United States
University of Vermont
Burlington, Vermont, United States
Virginia Commonwealth University
Richmond, Virginia, United States