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An Integrated Radio-immunological Approach
Sponsor: Istituto Oncologico Veneto IRCCS
Summary
The most aggressive primary brain tumors in adults, glioblastomas, are characterized by a profound local and systemic immune suppression. During tumor progression, the infiltration of inflammatory leukocytes, especially of myeloid origin, endowed with immunosuppressive function is observed. Aim of this study is to evaluate myeloid cell infiltrate and iron metabolism in tumor-associated macrophages by combining a multimodal MRI imaging technique with immunophenotyping of the tumor microenvironment.
Official title: Identification of the Immuno Suppressive Characteristics of Glioma Patients by an Integrated Radio-immunological Approach
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
31
Start Date
2022-02-23
Completion Date
2026-12-31
Last Updated
2026-01-23
Healthy Volunteers
No
Conditions
Locations (2)
University Hospital
Florence, Italy
University Hospital
Padova, Italy