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Combining Data Sources to Identify Effect Moderation for Personalized Mental Health
Sponsor: Johns Hopkins Bloomberg School of Public Health
Summary
This work will extend and apply methods for modeling heterogeneous treatment effects when multiple studies are available, with a particular focus on the complexities in mental health research. The methods will be illustrated in examples estimating the effects of medical treatments for major depressive disorder (duloxetine and vortioxetine) using 4 randomized controlled trials (available in the Vivli trials resource) and non-experimental data from the Duke University Health System electronic health record and the Johns Hopkins Health System electronic health record systems.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
9586
Start Date
2015-01-01
Completion Date
2024-12-01
Last Updated
2026-04-13
Healthy Volunteers
Not specified
Conditions
Interventions
Duloxetine, Vortioxetine
Medications for major depressive disorder
Locations (1)
Johns Hopkins Bloomberg School of Public Health
Baltimore, Maryland, United States