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Predictors of Cognitive Outcomes in Geriatric Depression
Sponsor: David Steffens
Summary
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well as factors that might minimize those effects, lead to particular mood and cognitive outcomes will inform future development of novel prevention strategies.
Official title: Phenotype Predictors of Cognitive Outcomes in Geriatric Depression
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
75
Start Date
2021-09-28
Completion Date
2026-06-30
Last Updated
2025-07-10
Healthy Volunteers
No
Interventions
Sertraline, bupropion, desvenlafaxine
Study geriatric psychiatrists prescribe FDA-approved antidepressants using a treatment algorithm consistent with the STAGED (Duke Somatic Treatment Algorithm for Geriatric Depression) approach, with standardization of treatment in the first six months beginning with sertraline, with the option of augmentation with bupropion or switch to desvenlafaxine. Beyond six months of acute treatment, subjects are treated based on the study psychiatrist's clinical assessment and recommendations, consistent with STAGED guidelines.
Locations (1)
UConn Health
Farmington, Connecticut, United States