Inclusion Criteria:
* Aged 18 to 80 years old
* The subject has a diagnosis of Grade ≤2 primary OA of the target hip
* Pain ≥ 40 on VAS scale
* The subject has groin pain that is elicited by hip rotation on physical examination
* No history of significant organ system disorders.
* Body mass index (BMI) \<40 kg/m2
* Systolic blood pressure of 100 to 160 mmHg and diastolic blood pressure of 60 to 90 mmHg.
* Using birth control
* Written informed consent
Exclusion Criteria:
* The subject exhibits severe symptoms in the target hip that result in difficulty or an inability to walk.
* The subject has severe hip OA ipsilateral to the target hip.
* Previous cartilage transplantation procedure to the injured cartilage surface.
* Major injury to the target hip within 12 months of screening.
* Active dermal ulcer or infection in the proximity of the target hip within 1 month before screening.
* The subject has had surgery on the target hip within the last 6 months.
* Total hip replacement surgery or other surgery on the target hip in the next 12 months.
* MRI indicates bone marrow infiltration, fracture, osteonecrosis/bone infarct, osteochondritis dissecans, tumor, moderate to severe dysplasia, avascular necrosis, post-traumatic arthritis, transient osteoporosis, slipped-cap femoral epiphysis, juvenile idiopathic arthritis, or axial juvenile spondyloarthritis.
* Hip conditions including but not limited to any autoimmune or infectious cause for arthritis; metabolic joint disease; neuropathic disorders, groin pain from non-orthopedic sources, or tumors, congestive heart failure, or chronic kidney disease.
* Uncontrolled diabetes based on a hemoglobin A1c (HbA1c) value \>8% at the screening Visit.
* Increased risk for post-procedure bleeding or post-procedure infection.
* Ongoing infectious disease, including, but not limited to, HIV, hepatitis C, or current or prior hepatitis B.
* Cognitive impairment that would limit his/her ability to provide informed consent or to complete assessments and questionnaires.
* 1 year history of drug or alcohol abuse.
* Contraindication to or cannot undergo MRI.
* Active malignancy within the last 5 years.
* Pregnant or is lactating.
* Taken steroidal or NSAIDs within 14 days before the Baseline Visit
* Using topical analgesics on the target hip
* Receiving chronic narcotic treatment at screening.
* Received any injection to the target hip within the 3 months before the Baseline Visit.
* Taking antiplatelet or anticoagulants.
* Participated in an investigational study within 13 weeks before the Screening Visit or in the next 25 months.
* Unable to comply with the requisite study follow-up and all of the follow-up office visits.
