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Recovery Rate in Secondary Hypothyroidism
Sponsor: Nova Scotia Health Authority
Summary
The aim of this project is to assess the rate of recovery of secondary hypothyroidism in patients with pituitary disorders.
Official title: Rate of Recovery of Secondary Hypothyroidism in Patients With Pituitary Disorders.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
90
Start Date
2022-04-04
Completion Date
2025-12-31
Last Updated
2024-08-21
Healthy Volunteers
No
Conditions
Interventions
Levothyroxine
Step 1: * Reduce the dose of T4 therapy by 50% and recheck serum T4 after 2 weeks. * If serum T4 is normal, go to step 2. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 2: * Discontinue T4 therapy altogether and recheck serum TSH and T4 after 2 weeks. * If serum T4 is normal, go to step 3. * If serum T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure). Step 3: * Recheck serum TSH and T4 after 8 weeks. * If serum TSH and T4 levels are normal, these patients will be regarded as having successful T4 withdrawal. * If T4 drops to below normal then resume full T4 replacement (these patients will be considered as having withdrawal failure).
Locations (1)
Nova Scotia Health
Halifax, Canada