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RECRUITING
NCT05282251
NA

Intrapleural Nebulization of Bupivacain to Reduce Postoperative Pain

Sponsor: Assiut University

View on ClinicalTrials.gov

Summary

Thoracic surgery is now common and as other surgeries evolution of minimally invasive techniques is employed. Video-assisted thoracic surgery (VATS) produces little scar but may produce severe pain that may affect the pulmonary function. Many procedure was developed like intercostal nerve block which require injections at multiple levels, Insertion of local anaesthetic (LA) in the surgical drain but that was dangerous due to the large amount of LA and not sufficient to completely eliminate pain. Bupvicaine nebulization, through surgical port which won't make any other wound, thought to be sufficient because Nebulization will enable us better distribution and less amounts of LA. Bupvicaine is local anaesthetic amide group that works by blocking sodium channels thus preventing progression of action potential.

Official title: Pain Managment After VATS to Reduce Postoperative Pain and Improve Pulmonary Function

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2024-05-17

Completion Date

2024-07-15

Last Updated

2024-05-20

Healthy Volunteers

No

Conditions

Interventions

DRUG

Intrapleural bupivacine nebulization

Intrapleural nebulization of bupivacine (10 ml of bupivacaine 0.5%) + Intravenous normal saline as a placebo

DRUG

Intravenous paracetamol and ketorolac

Intravenous analgesia: paracetamol (one gram) and Ketorolac (30 mg) + Intrapleural normal saline (10 ml) as a placebo

Locations (1)

Assiut University

Asyut, Assuit, Egypt