Clinical Research Directory

Inclusion Criteria: 1. Patients who have chronic kidney disease(CKD) stages 3-5 2. Aged between18 - 60 years old. 3. Both sexes. 4. Stable clinical condition defined as no hospitalizations or cardiovascular events within the 3 months before screening 5. Stable renal function (baseline serum creatinine had to have not increased by 50% in the 3 months before screening) 6. No changes in concomitant medication during the study. 7. Patients who accept to participate in the study. Exclusion Criteria: 1. Pregnant women 2. Current use of PTF 3. Contraindication to use of PTF drug: history of PTF or theophylline allergy, history of severe retinal hemorrhage or recent cerebral hemorrhage 4. Those with active infections or inflammatory diseases or HIV infection 5. Those with chronic liver disease . 6. Patients who had received immunosuppressive therapy 7. Non-compliant patients