Clinical Research Directory

Inclusion Criteria: * symptomatic adult patients diagnosed with chronic pancreatitis and pancreatic duct stones; * stones (≤5 mm in diameter) are located in the main pancreatic duct of the pancreatic head/body with dilation of the proximal pancreatic duct. Exclusion Criteria: * suspected to have malignant tumors; * history of pancreatic surgery or gastrojejunostomy (Billroth II); * bile duct stricture secondary to cholangitis or chronic pancreatitis; * acute pancreatitis exacerbation or acute exacerbation of chronic pancreatitis (including biliary pancreatitis); * there is a stent in the main pancreatic duct; * coagulation dysfunction (INR≥1.5 or platelet count≤50×10\^9/L); * pregnant or breastfeeding women; * patients who refused to participate in the study.