Clinical Research Directory
Browse clinical research sites, groups, and studies.
the PHENOSAR Trial: Use of Antibiotics in Treatment of Sarcoidosis
Sponsor: St. Antonius Hospital
Summary
In this study it is investigated whether treatment with azithromycin in combination with doxycycline reduces the bacterial load of C. acnes in granulomatous tissue of patients with sarcoidosis and subsequently decreases the inflammatory activation measured by FDG uptake and serum biomarkers.
Official title: PHENOtype Based Therapy With Antibiotics in SARcoidosis Patients With and Without Presence of Cutibacterium Acnes in Granulomatous Tissue
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2023-02-15
Completion Date
2026-12-01
Last Updated
2026-02-12
Healthy Volunteers
No
Conditions
Interventions
FDG-PET/CT
Patients will be randomized in a 1:1 ratio to either receive a combination of doxycycline and azithromycin or placebo during 3 months, after which the inflammatory state of disease is measured by FDG-PET/CT and serum biomarkers. If patients have cutaneous sarcoidosis, a skin biopsy will be performed at baseline and at the end of the study.
Locations (1)
St. Antonius Hospital
Nieuwegein, Utrecht, Netherlands