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Are Mast Cells Involved in Autoinflammatory Diseases
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Autoinflammatory diseases (AID) are caused by innate immunity dysregulation. AID pathophysiology is only partly understood, especially in the case of unclassified AID. Mast cells (MC) are innate immune cells associated with a spectrum of disease between systemic mastocytosis and mast cell activation syndrome. The implication of MC has been shown in cryopyrin associated periodic syndrome (CAPS).Our aim is to evaluate the involvement of MC in AID by assessing clinical and biological signs of MC activation and studying cutaneous and digestive biopsies.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
590
Start Date
2022-03
Completion Date
2026-10
Last Updated
2022-03-23
Healthy Volunteers
Not specified
Conditions
Locations (1)
Service de Médecine Interne
Paris, France