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Vascular Aging and Lp299v Study
Sponsor: Medical College of Wisconsin
Summary
Emerging data suggest the gut microbiota regulates multiple mechanisms related to vascular aging, but no intervention targeting the gut microbiota has been tested in older adults without cardiovascular risk factors or cardiovascular disease. Early human data suggest an increase in potentially pathological gut metabolites such as trimethylamine-N-oxide (TMAO) are associated with older age, increased vascular stiffness, increased oxidative stress, and reduced nitric oxide (NO) bioavailability as evidenced by impaired endothelium-dependent vasodilation. Based on this data, the investigators hypothesize that supplementation with Lp299v will reverse human vascular aging in healthy older adults free of known traditional cardiovascular risk factors.
Official title: Impact of Lp299v on Vascular Aging in Healthy Adults
Key Details
Gender
All
Age Range
50 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2023-02-01
Completion Date
2027-09-22
Last Updated
2025-04-27
Healthy Volunteers
Yes
Conditions
Interventions
Lactobacillus Plantarum 299v in fermented oat drink
The intervention is a probiotic lactobacillus that is contained in food products in the US
Heat-Killed Placebo control fermented drink
The intervention is the GoodBelly StraightShort that has been treated to heat kill all Lp299v
Locations (1)
Medical College of Wisconsin
Milwaukee, Wisconsin, United States