Clinical Research Directory

Inclusion Criteria: 1. Patient with untreated large B cell lymphoma requiring a first line treatment by RCHOP or R-mini-CHOP 2. Patient aged 18 years or older at the time of signing Informed Consent Form 3. Additional Intrathecal or/and intravenous treatment with Methotrexate allowed, if indicated 4. Eastern Cooperative Oncology Group (ECOG) Performance Status \< 3 5. Patient with internet access (or has someone at home who can help send patients' symptoms or complete the form) 6. Patient enrolled in social security 7. Patient has given his written consent ahead of any specific protocol procedure Exclusion Criteria: 1. Patient with symptomatic brain metastases, 2. Patient deprived of their liberty, under guardianship or trusteeship 3. Patient is being treated for another cancer and has not been cured 4. Patient with dementia, mental disorders or psychological pathology which could compromise patient informed consent and/or the observance of the study protocol 5. Patient cannot submit to the protocol for psychological, social, familial or geographical reasons 6. Patient is pregnant or breastfeeding