Clinical Research Directory
Browse clinical research sites, groups, and studies.
Dexamethasone to Target Stress and Immune System Mechanisms Underlying Alcohol Craving
Sponsor: Stony Brook University
Summary
This is a double-blind, placebo-controlled, proof of concept laboratory study to recruit N=70 (35 Males / 35 Females) non-treatment seeking, heavy drinkers with alcohol use disorder (AUD). It is hypothesized that randomization to 1.5mgs dexamethasone versus placebo will decrease alcohol craving during stress by decreasing basal cortisol, increasing anti-inflammatory cytokine levels and potentially normalizing the immune response to stress.
Official title: Dexamethasone to Target Stress and Immune System Changes During Early Abstinence in Individuals With Alcohol Use Disorder (AUD)
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
27
Start Date
2022-03-11
Completion Date
2024-06-30
Last Updated
2026-10-02
Healthy Volunteers
No
Conditions
Interventions
Dexamethasone Oral
1.5mg oral dexamethasone to be administered once at 11:00PM
Placebo
oral placebo to be administered once at 11:00PM
Locations (1)
The Health Sciences Center
Stony Brook, New York, United States