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Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
Sponsor: University of Southern California
Summary
This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.
Official title: Theta Burst Subthalamic Nucleus Deep Brain Stimulation for Cognitive and Motor Improvements in Parkinson's Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2022-01-11
Completion Date
2029-08-31
Last Updated
2025-06-11
Healthy Volunteers
No
Conditions
Interventions
STN DBS - Theta Burst
200 Hz intraburst stimulation for 0.1 second repeated at intervals of 5hz with an existing device
STN DBS - Gamma
Standard of care gamma stimulation with an existing device
Locations (1)
University of Southern California Keck School of Medicine
Los Angeles, California, United States