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Effects of Lactobacillus Plantarum PS128 in Children With ASD
Sponsor: Chang Gung Memorial Hospital
Summary
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can cause significant social, communication and behavioral deficits. Probiotics are regarded as active microorganisms. With sufficient amounts, probiotics can regulate intestinal flora, intestinal permeability, inflammation and antioxidant reactions in the body. These reactions may further promote health, regulate metabolic disease progression and prevent complications. Lactobacillus plantarum PS128 (PS128) was reported to be a psychobiotic in several animal and human studies which modulated the levels of neurotransmitters in different brain areas. This study is to evaluate whether the consumption of PS128 can improve the symptoms of patients with ASD. The current randomized, placebo-controlled trial was conducted to investigate the psychophysiological effects of PS128 in school children with ASD.
Official title: Effects of Lactobacillus Plantarum PS128 in Children With Autism Spectrum Disorder
Key Details
Gender
All
Age Range
7 Years - 12 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2022-07-15
Completion Date
2026-12-31
Last Updated
2023-08-31
Healthy Volunteers
Yes
Conditions
Interventions
PS128
Each PS128 capsule contained \>3 × 10\^10 colony forming units (CFU) with microcrystalline cellulose and weights 425 ± 25 mg.
Placebo
The placebo capsules only contained 425 ± 25 mg microcrystalline cellulose.
Locations (1)
Chang Gung Memorial Hospital
Taoyuan District, Taiwan