Clinical Research Directory
Browse clinical research sites, groups, and studies.
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
Sponsor: Yale University
Summary
This is a prospective randomized placebo-controlled double-blind crossover pilot study determining the effect of dichloroacetate on brain function under clamped hypoglycemia in T1DM.
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2025-05-13
Completion Date
2026-06-30
Last Updated
2025-07-03
Healthy Volunteers
No
Interventions
Dichloroacetate
Dichloroacetate has a long safety record of administration to humans with a rare metabolic disorder for over 40 years. It has been given orally to patients with T2DM for up to a week without any problems and other laboratory or significant clinical adverse effects were not noted. It activates mitochondrial PDH flux, a key regulator of glucose oxidation.
Locations (1)
Yale-New Haven Hospital
New Haven, Connecticut, United States