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Effect of Chronotherapy on Blood Pressure - Time of Intake of Blood Pressure Lowering Drugs
Sponsor: Vastra Gotaland Region
Summary
A randomized clinical trials with cross-over design to evaluate changes in blood pressure, renal function (creatinine, estimated glomerular filtration), LDL and HDL-cholesterol after taking antihypertensive drugs in the morning or at bedtime. Blood pressure will be estimated by ambulatory blood pressure measurements. There will be a shift in time of drug intake after 8 weeks for each participant. Approximately 100 individuals aged 40-75 years and on stable anti-hypertensive treatment and blood pressure \<150/95 mm Hg will be recruited. No new drugs will be introduced during the study.
Official title: Chronotherapy in Hypertension - a Study of Blood Pressure Levels Following Intake of Antihypertensive Medication in the Morning or at Bedtime
Key Details
Gender
All
Age Range
40 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2022-06-25
Completion Date
2025-06-01
Last Updated
2024-08-20
Healthy Volunteers
No
Interventions
Time of ordinary antihypertensive medication intake
Time of ordinary antihypertensive medication intake
Locations (3)
Sahlgrenska University Hospital, Mölndal
Gothenburg, Sweden
Närhälsan Billingen Primary Health Care Centre
Skövde, Sweden
Närhälsan Norrmalm Primary Health Care Centre
Skövde, Sweden