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Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
Sponsor: Boston Children's Hospital
Summary
The use of peri-arrest bolus epinephrine (PBE) has emerged as a rescue strategy for life-threatening hypotension in pediatric intensive care units (ICU) despite scant published data supporting its use in this setting. As optimal dosing of PBE in this population is unclear, we aim to determine if an initial dose of 0.5 mcg/kg versus 1.0 mcg/kg yields differences in hemodynamic outcomes. The EPI Dose Study is a single-center, prospective, randomized, double-blind, dose-effect trial measuring systolic blood pressure (SBP) before and after PBE is given. We hypothesize that the 1.0 mcg/kg group will have more robust increases in SBP.
Official title: Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial (EPI Dose)
Key Details
Gender
All
Age Range
Any - 25 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2023-02-08
Completion Date
2025-05-16
Last Updated
2026-05-13
Healthy Volunteers
No
Conditions
Interventions
Epinephrine 0.5 mcg/kg
Syringe with 5 mcg/mL epinephrine
Epinephrine 1 mcg/kg
Syringe with 10 mcg/mL epinephrine
Locations (1)
Boston Children's Hospital
Boston, Massachusetts, United States