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RECRUITING
NCT05327829
EARLY_PHASE1

Stimulating After Recovery From Traumatic Brain Injury

Sponsor: University of Minnesota

View on ClinicalTrials.gov

Summary

This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and decision-making.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2025-03-31

Completion Date

2028-01-15

Last Updated

2026-04-07

Healthy Volunteers

Yes

Interventions

COMBINATION_PRODUCT

External non-invasive stimulation

The participants are randomized into the block design of sham or tACS during the first three appointments or the last three appointments. Eye tracking will be used to test the predominant focus of decisions during the gaze phase on costs or difficulty levels during the COGED. The study is investigating the use of neuromodulation after TBI for improved cognitive function.

BEHAVIORAL

COGED

The COGED task consists of the classic N-back task of working memory-based decision making, followed by a valuation phase. The N-back phase of the task allows calculation of cognitive performance of a working memory task. During valuation, participants receive titrating offers of differing amounts of money to perform different difficulty levels of the N-back. The result is an effort discounting curve used to measure the individual effort cost. Effort discounting curves show the perceived cognitive effort required to complete each level of the task relative to another (typically the 1-back).

Locations (1)

Hennepin County Medical Center

Minneapolis, Minnesota, United States