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Serum Rennin Kinetics Versus Serum Lactate Kinetics as Predictors of Mortality in Septic Shock Patients
Sponsor: Assiut University
Summary
Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospital mortality in septic shock patients.
Official title: Serum Renin Kinetics Versus Serum Lactate Kinetics as Predictors of Mortality in Septic Shock Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2025-01-10
Completion Date
2025-06-30
Last Updated
2026-08-21
Healthy Volunteers
No
Conditions
Interventions
Plasma renin concentrations will be measured at enrollment and at 24, 48, and 72 hours. Whole blood lactate measurements will be performed according to normal standard of care.
Arterial blood gas samples, obtained at enrollment and at 24, 48, and 72 hours, were analyzed for lactate concentration using the ABL 800 series analyzer (Radiometer America, Brea, California, USA). Blood for these measurements was drawn into lithium-heparinized tubes. Lactate clearance was calculated at 24, 48, and 72 hours according to the following formula: Lactate Clearance (%) = \[(Baseline Lactate - Lactate at Time t) / Baseline Lactate\] × 100. An ELISA kit developed and manufactured by DRG International (Springfield Township, NJ, USA) was used to determine plasma concentrations of active renin. Blood samples were collected in EDTA tubes at baseline and at 24, 48, and 72 hours.. Plasma was separated from centrifuged samples and stored at -80°C for a maximum of 6 months until batch analysis. All samples were analysed in a single batch, and laboratory personnel were blinded to patient outcome. The assay was based on the sandwich ELISA principle
Locations (1)
Omar Ali
Asyut, Egypt