Clinical Research Directory

Inclusion Criteria: * Women who are 40 - 50 years of age or older and have not gone through menopause according to Stages of Reproductive Aging Workshop (STRAW) 2011 * The last menstrual period before participating in the study at least 2 months or more * FSH, Estrogen above the menopause: * \+ FSH \> 40 mIU/mL * \+ Estradiol \< 30 pg/mL * (tested between the 2nd and the 4th day of the menstrual cycle) * FSFI \< 26.55 ± signs of decline in sexual or reproductive functions such as symptoms of premenopausal such as hot flashes, excessive sweating, headaches * Normal liver function * Normal kidney function * Normal cardiovascular function * No active bacterial, fungal and viral (HIV, HBV, HCV, syphilis) infections * Provide written informed consent Exclusion Criteria: * Previous surgery to remove gonads * No sexual activity * Diagnosed with cancer and is being or has not been treated * Had an organ transplant * Has congenital malformations related to the gonads * Chronic disease such as: Diabetes, hypopituitarism, adrenal insufficiency, blood pressure unresponsive to treatment, etc * Any active autoimmune diseases * Being diagnosed with heart failure, kidney failure, liver failure, respiratory failure, history of cerebral infarction, myocardial infarction, Alzheimer's * Hypothyroidism or hyperthyroidism * Any active autoimmune diseases * Any clinically significant blood coagulation disorders. * History of allergic reaction to anesthetic agents and antibiotics * Using hormone therapy within the last 2 weeks or want to use these drugs during the study period * Planning to become pregnant during the study period * using hormonal contraceptives * Absence of menstruation for at least 12 months * Mental illness, inability to communicate, inability to answer the interview questions correctly