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Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach
Sponsor: Charite University, Berlin, Germany
Summary
The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors. It will follow 200 healthy transgender individuals for two years during their hormone replacement therapy (HRT) and analyze them for the possible emergence of cardiovascular risk factors in relation to changes in the gut microbiome, metabolome, and immunome. We would also like to phenotype cardiovascular disease.
Official title: Sex Hormone-specific Cardiovascular Risks in the Gut Microbiome-host Axis - A Longitudinal Cohort Study.
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2022-08-29
Completion Date
2027-12-31
Last Updated
2024-02-09
Healthy Volunteers
Not specified
Locations (1)
Experimental and Clinical Research Center, Clinical Research Unit
Berlin, Germany