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RECRUITING
NCT05334927

China HeadAche DIsorders RegiStry

Sponsor: Beijing Tiantan Hospital

View on ClinicalTrials.gov

Summary

It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS), patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected. The biomarkers, imaging features, cognition, genetic characteristics, ocial and demographic data, medical data, therapeutics used, and outcome of headache-related diseases were studied, and long-term follow-up was planned.

Key Details

Gender

All

Age Range

12 Years - Any

Study Type

OBSERVATIONAL

Enrollment

10000

Start Date

2022-08-29

Completion Date

2032-12-31

Last Updated

2026-01-15

Healthy Volunteers

No

Interventions

BEHAVIORAL

Medicine Overuse Headache/New Daily Persistent Headache

At the end of the 24th month visit, the patient is free to choose whether to conduct a face-to-face visit once a year until death.

BEHAVIORAL

Episodic Migraine and Chronic Migraine

long-term follow-up

BEHAVIORAL

Patients with other types of primary headache

No collection Brain imaging、Cognitive function test、Biological sample

DRUG

Yangxue Qingnao Granules (Pills)

Participants who, in routine clinical practice, were prescribed Yangxue Qingnao Granules/Pills for acute headache relief and/or preventive management were enrolled. Treatment initiation, dosing, frequency, and duration were determined by the treating physician and the patient and were not assigned by the study protocol. During the 12-week observation period, participants were followed and outcomes were recorded, including relief of up to four headache episodes (for those using the medication for acute treatment) and longitudinal symptom measures at weeks 4, 8, and 12 (for those receiving preventive management).

BIOLOGICAL

Erenumab

Participants who received eptinezumab for migraine prophylaxis in routine clinical practice were included. Treatment decisions (including whether to initiate eptinezumab, the selected dose \[e.g., 100 mg or 300 mg\], infusion interval, and duration) were made by the treating physician in consultation with the patient, and were not assigned by the study protocol. Patients were followed prospectively/retrospectively according to routine clinic visits, with outcome assessments captured at approximately 4-week intervals during the 12-week observation window (and additional follow-up when available).

BIOLOGICAL

Eptinezumab

Participants who received eptinezumab for migraine prophylaxis in routine clinical practice were included. Treatment decisions (including whether to initiate eptinezumab, the selected dose \[e.g., 100 mg or 300 mg\], infusion interval, and duration) were made by the treating physician in consultation with the patient, and were not assigned by the study protocol. Patients were followed prospectively/retrospectively according to routine clinic visits, with outcome assessments captured at approximately 4-week intervals during the 12-week observation window (and additional follow-up when available).

Locations (20)

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Beijing Chaoyang Hospital

Beijing, Beijing Municipality, China

Chongqing People's Hospital

Chongqing, Chongqing Municipality, China

Fujian Provincial Hospital

Fuzhou, Fujian, China

The First Affiliated Hospital of Guangxi University of Chinese Medicine

Nanning, Guangxi, China

The First People's Hospital of Zunyi

Zunyi, Guizhou, China

Ruijin-Hainan Hospital Shanghai Jiao Tong University School Of Medicine

Qionghai, Hainan, China

Zhangjiakou First Hospital

Zhangjiakou, Hebei, China

Luohe Central Hospital

Luohe, Henan, China

Luoyang Central Hospital

Luoyang, Henan, China

The Second Affiliated Hospital of Henan University of Science and Technology

Luoyang, Henan, China

The 7th People's Hospital of Zhengzhou

Zhengzhou, Henan, China

Changzhou First People's Hospital

Changzhou, Jiangsu, China

Jiujiang First People's Hospital

Jiujiang, Jiangxi, China

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Huludao Central Hospital

Huludao, Liaoning, China

Zibo Municipal Hospital

Zibo, Shandong, China

Dachuan District People's Hospital

Dazhou, Sichuan, China

Deyang People's Hospital

Deyang, Sichuan, China

The First People's Hospital of Guangyuan

Guangyuan, Sichuan, China