Clinical Research Directory

Inclusion Criteria: * Age 18 years or older * Patient who will undergo arthroscopic surgery of the knee including, but not limited to, * Meniscectomy * Synovectomy * Chondroplasty * Loose body removal Exclusion Criteria: * Patients under age 18 years * Patients who cannot provide consent * Patients who are pregnant, breast feeding, or are trying to become pregnant during the study period * Patients with an allergy to any of the study drugs * Patient who are lactose-intolerant * Revision surgery * Open surgery * Comorbidities preventing surgery * Patients with a history of mania, depression, or schizophrenia * Patients taking any of the following drugs or supplements * Anticholinergic agents * Benzodiazepines * Central nervous system depressants * Droperidol * Hydroxyzine * Levomepromazine or methotrimeprazine * Monoamine oxidase inhibitors * Ritonavir * Selective serotonin reuptake inhibitors * Sympathomimetics * St. John's Wort * Current diagnosed alcohol or drug abuse * Patients who cannot or will not abide by the medication restrictions listed below Medication restrictions * Participants must agree to abstain from using recreational or medical marijuana products or cannabidiol (CBD) in any form during the treatment period * Participants should not drink alcohol or take other drugs while taking the study drug or hydrocodone/acetaminophen