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Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
Sponsor: University of Pittsburgh
Summary
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times, which may increase the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to modify these disruptions is unknown. Project 1 (P1), specifically examines homeostatic and circadian characteristics as mechanisms linking habitual sleep patterns, reward and cognitive control (at subjective, behavioral, and circuit levels), and longitudinal substance use risk.
Official title: Center for Adolescent Reward, Rhythms and Sleep Project 1
Key Details
Gender
All
Age Range
13 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2022-03-04
Completion Date
2030-05-31
Last Updated
2026-04-08
Healthy Volunteers
Yes
Conditions
Interventions
Ultradian sleep/wake protocol
120-minute schedule, consisting of 80 minutes awake followed by a 40 minute sleep opportunity for up to 36 hours
Locations (1)
Western Psychiatric Hospital
Pittsburgh, Pennsylvania, United States